An injectable, self-healing and degradable hydrogel scaffold as a functional biocompatible material for tissue engineering applications

Abstract Injectable hydrogels derived from natural extracellular matrices exhibit excellent adhesion to endothelial cells in vitro and are ideal for many biomedical applications. However, their applicability vivo is limited by the risk of infection or immunogenicity, current injectables also suffer degradation, viscosity, drug release. In this study, a multifunctional hydrogel scaffold (COB hydrogels) was constructed incorporating bioactive glass nanoparticles with Schiff base crosslinking-based composed carboxymethyl chitosan oxidized cellulose. The incorporation not only shortened gelation time COB hydrogels, but enhanced performance terms function, such as loading capacity. prepared have self-healing ability, injectability, sustained release, antibacterial properties biocompatibility. addition, given no cytotoxicity mild inflammation vivo, scaffolds will be important tissue engineering delivery